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Image Search Results
Journal: Frontiers in Immunology
Article Title: GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer
doi: 10.3389/fimmu.2025.1512086
Figure Lengend Snippet: GNA15 is a differentially expressed gene for drug resistance. (A) Differential gene expression analysis on the GSE33482 database, red points represent upregulated genes, and green points represent downregulated genes. (B) The intersection of 1598 drug resistance related DEGs and 18 prognostic M2-like TAM-related genes. (C, D) GNA15 expression between cisplatin-resistant cells of ovarian cancer cell and corresponding OC cells by qRT-PCR analysis. *p < 0.05; **: p < 0.01.
Article Snippet:
Techniques: Gene Expression, Expressing, Quantitative RT-PCR
Journal: Frontiers in Immunology
Article Title: GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer
doi: 10.3389/fimmu.2025.1512086
Figure Lengend Snippet: GNA15 expression in normal and cancer tissues. (A) RNA-Seq analysis using TCGA-OV samples and matched normal control samples from the GTEx project. (B) ROC analysis of GNA15 expression for the discrimination between OC and normal controls using TCGA-OC samples and matched normal control samples from the GTEx project. (C) qRT-PCR analysis using OC cells and normal ovarian cells. (D) qRT-PCR analysis using clinical OC and normal control samples. (E) IHC was performed to detect the expression of GNA15 in OC and normal tissues. (F–I) Survival analysis comparing the high and low expression of GNA15 in OC patients based on TCGA-OC database, GSE3149, GSE63885 and our clinical samples. *p < 0.05; **: p < 0.01; *** p < 0.001.
Article Snippet:
Techniques: Expressing, RNA Sequencing, Control, Quantitative RT-PCR
Journal: Frontiers in Immunology
Article Title: GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer
doi: 10.3389/fimmu.2025.1512086
Figure Lengend Snippet: Down-regulating GNA15 in vitro decreased ovarian cancer cell proliferation. (A) knock down of GNA15 in OVCAR5 and OVCAR8 using ShRNA and CRISRP-Cas9. (B) Down-regulating GNA15 significantly decreased ovarian cancer cell proliferation. The protein data were normalized to β-actin. *** p < 0.001.
Article Snippet:
Techniques: In Vitro, Knockdown, shRNA